SEMGLEE and Insulin Glargine (insulin glargine-yfgn)
injection: Insulin Vial

Product Vials and Product Packshot Image
Product Vials and Product Packshot Image

SEMGLEE and Insulin Glargine (insulin glargine-yfgn)
injection: Insulin Vial

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SEMGLEE and Insulin Glargine (insulin glargine-yfgn) are also available in a 10 mL vial 100 units/mL (U-100).


  • Vial Icon The 10 mL vial
  • Image of Needle A U-100 insulin syringe and needle. Needles are sold separately
  • Image of Alcohol Wipes Alcohol wipes
  • Sharps Disposal Container Icon 1 sharps disposal container for throwing away used needles and syringes

†  Learn more on disposing of used needles and syringes


Checkmark IconDO
  • Hand WashingWash your hands with soap and water or clean them with rubbing alcohol.
  • Check MarkCheck the SEMGLEE label to make sure you are taking the right type of insulin. This is especially important if you use more than one type of insulin.
  • Syringe Icon Always use a syringe that is marked for U-100 insulin. If you use a syringe other than a U-100 insulin syringe, you could be administering an incorrect dose.
  • Syringe in Package Icon Always use a new syringe or needle for each injection. Do not reuse or share your syringes or needles with other people. You may give other people a serious infection or get a serious infection from them.
X Symbol IconDON'T
  • Bottle with X Symbol Do not use SEMGLEE if it is colored or cloudy or if you see particles in the solution.
  • Labeling with X Symbol Do not use SEMGLEE after the expiration date stamped on the label or 28 days after you first use it.
  • Recycle Icon Do not reuse syringes.
  • Needle with X Symbol Icon Do not share syringes or needles with other people, even if the needle has been changed. You could give other people a serious infection or get a serious infection yourself.

Notebook Icon INSTRUCTIONS FOR USE SEMGLEE® (insulin glargine-yfgn) injection for subcutaneous use 10 mL Vial 100 units/mL (U-100)

  • Step 1

    • If using a new vial, remove the protective cap. Do not remove the rubber stopper.

      Removing Protective Cap From Vial

  • Step 2

    • Wipe the top of the vial with an alcohol wipe. You do not have to shake the vial before use.

      Cleaning Top of Vial with Alcohol Wipe

  • Step 3

    • Draw air into the syringe equal to the insulin dose. Put the needle through the rubber top of the vial and push the plunger to inject the air into the vial.

      Pushing Plunger to Inject Air into the Vial Once Needle is Through Rubber Top and Drawing Air into Syringe

  • Step 4

    • Leave the syringe in the vial and turn both upside down. Hold the syringe and vial firmly in one hand. Make sure the tip of the needle is in the insulin. With your free hand, pull the plunger to withdraw the correct dose into the syringe.

      Vial is Upside Down with Inserted Syringe, Pulling the Plunger to Correct Dose

  • Step 5

    • Before taking the needle out of the vial, check the syringe for air bubbles. If bubbles are in the syringe, hold the syringe straight up and tap the side of the syringe until the bubbles float to the top. Push the bubbles out with the plunger and draw insulin back in until you have the correct dose.

      Tapping Syringe Before Removing Syringe From Vial

  • Step 6

    • Remove the needle from the vial. Do not let the needle touch anything.

      Administer the SEMGLEE injection:

      • Inject insulin exactly as healthcare provider has discussed with you.
      • Inject insulin under the skin (subcutaneously) of your upper legs (thighs), upper arms, or stomach area (abdomen).
      • Change (rotate) injection site within the area chosen for each dose to reduce risk of getting pits in the skin or thickened skin (lipodystrophy), and skin with lumps (localized cutaneous amyloidosis) at the injection sites.
      • Do not inject where the skin has pits, is thickened, or has lumps.
      • Do not inject where the skin is tender, bruised, scaly or hard, or into scars or damaged skin.

      Image of Human Body - Front and back View

  • Step 7

    • Choose injection site. Wipe the skin with an alcohol wipe to clean the injection site. Let the injection site dry before injecting dose.

      Wiping Injection Site with Alcohol Wipe

  • Step 8

    • Pinch the skin.
    • Insert the needle in the way your healthcare provider showed you.
    • Release the skin.
    • Slowly push in the plunger of the syringe all the way, making sure all the insulin has been injected.
    • Leave the needle in the skin for about 10 seconds.
    • Injecting Needle into Body in Area of Pinched Skin

  • Step 9

    • Pull the needle straight out of skin. Gently press the injection site for several seconds. Do not rub the area. Do not recap the used needle since it can lead to a needlestick injury.


Sharps Container IconLaundry Detergent Container with X Symbol

  • Put your used needles and syringes in an FDA-cleared sharps disposal container right away after use. Do not throw away (dispose of) loose needles and syringes in your household trash.
  • If you do not have an FDA-cleared sharps container, you may use a household container that is:
    • made of a heavy-duty plastic,
    • can be closed with a tight-fitting, puncture-resistant lid, without sharps being able to come out,
    • upright and stable during use,
    • leak resistant, and
    • properly labeled to warn of hazardous waste inside the container.
  • When the sharps disposal container is almost full, follow your community guidelines for the correct disposal of your sharps container. There may be state or local laws about how to throw away used needles and syringes.
  • Do not dispose of a sharps container in a household trash unless community guidelines permit this. Do not recycle your used sharps disposal container.
  • For more information about safe sharps disposal, and for specific information about sharps disposal in the state that you live in, go to the FDA’s website at:


  • Store Unused Semglee VialsStore unused SEMGLEE vials in the refrigerator between 36° and 46°F (2° to 8°C) until the expiration date. If the unopened SEMGLEE vial is stored at room temperature, up to 86°F (30°C), it should be thrown away after 28 days.
  • 86 Degrees IconStore in-use (opened) SEMGLEE vials in a refrigerator or at room temperature up to 86°F (30°C).
  • The SEMGLEE VialsThe SEMGLEE vials should be thrown away after 28 days, even if it still has insulin left in it.
  • Snowflake with X Symbol Do not  freeze SEMGLEE.
  • Sunlight with X SymbolKeep SEMGLEE out of direct heat and light.
  • Frozen or OverheatedIf a vial has been frozen or overheated, throw it away.